There's a launch of norepinephrine through the descending inhibitory bulbospinal neurons that binds to alpha-two-receptors inside the dorsal horn to decrease afferent pain transmission and make analgesia. For that reason, drugs like clonidine that focus on alpha-two receptors can impact the transmission of agony. Applies to clonidine: oral tablet, https://gogogobookmarks.com/story19803062/detailed-notes-on-onolidine