There exists a release of norepinephrine within the descending inhibitory bulbospinal neurons that binds to alpha-2-receptors inside the dorsal horn to decrease afferent pain transmission and generate analgesia. Thus, medicines like clonidine that focus on alpha-2 receptors can affect the transmission of discomfort. Clonidine is an extended-term medication. It https://willq036psv2.wikibriefing.com/user