An extensive literature critique of reports between 1995 and 2018 was performed using the electronic databases PubMed and EBSCO Host. Lookups were performed employing the next phrases: whole knee arthroplasty (TKA); cyclooxygenase-two inhibitors; bracing; physical therapy; weight reduction; knee; treatment; therapeutics; OA; intra-articular injection; hyaluronic acid; corticosteroid; ... https://www.theorthopaedicandpainpractice.com/non-surgical-treatments-for-knee-joint-pain/